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Coenzyme Q10 (CoQ10, ubiquinone, Vitamin Q10) is a compound found in every mitochondrion of all the cell in our bodies. The primary biochemical action of CoQ10 is as a cofactor in the electron-transport chain, the series of redox reactions that are involved in the synthesis of adenosine triphosphate(ATP). Since most cellular functions are dependent on an adequate supply of ATP, CoQ10 is essential for the health of virtually all human tissues and organs. Besides, with the ability to transfer electrons away from the cell membrane, CoQ10 is the intrinsic antioxidant to stability the cell membrane and prevent damage caused by harmful free radicals.
Although CoQ10 can be synthesized “in vivo”, situations may arise in which the body’s synthetic capacity is insufficient to meet CoQ10 requirements. Susceptibility to CoQ10 deficiency appears to be greatest in cells that are metabolically active (such as those in the heart, immune system, gingival, kidney). In addition, CoQ10 levels decline with advancing age, and this decline might contribute in part to some of the manifestations of aging. A need for supplemental CoQ10 could theoretically result from (1) impaired CoQ10 synthesis due to nutritional deficiencies, (2) Defect in CoQ10 synthesis due to intake of cholesterol lower medicines, or (3) increased tissue needs resulting from a particular illness. Since oral administration of CoQ10 can increase tissue levels of the nutrient, it is possible to correct CoQ10 deficiency and its associated metabolic consequences by supplementation.
Benefits of CoQ10 to our bodies:
Most muscle cells (heart muscles, body muscle, gingival, kidney) presumably have the highest requirements for CoQ10. Tissue deficiencies or subnormal serum levels of CoQ10 have been reported to occur in a wide range of medical conditions, including cardiovascular disease, hypertension, periodontal disease. Therefore, adequate intake of CoQ10 has been attributed to be beneficial of various diseases and sub-healthy conditions.
The processes of aging and photoaging are associated with an increase in cellular oxidation. This may be in part due to a decline in the levels of the endogenous cellular antioxidant coenzyme Q10 Therefore, supplementation of CoQ10, the active ingredient in Quten-visol, has the beneficial effect of preventing photoaging. Clinical studies have demonstrated that CoQ10 penetrated into the viable layers of the epidermis and reduce the level of oxidation measured by weak photon emission. Furthermore, a reduction in wrinkle depth following CoQ10 application was also shown. CoQ10 was determined to be effective against UVA mediated oxidative stress in human keratinocytes in terms of thiol depletion, activation of specific phosphotyrosine kinases and prevention of oxidative DNA damage. CoQ10 was also able to significantly suppress the expression of collagenase in human dermal fibroblasts following UVA irradiation.
The tendency to become overweight is associated in some cases with impaired energy production. This abnormality may be in part genetically determined. Individuals with a family history of obesity have a 50% reduction in their thermogenic response to meals, suggesting the presence of an hereditary defect in energy output. Since CoQ10 is an essential cofactor for energy production, it is conceivable that CoQ10 deficiency is a contributing factor in some cases of obesity. Serum levels of CoQ10 were found to below in 14 (52%) of 27 morbidly obese patients. In a clinical studies, nine of these 27 individuals (five with low CoQ10 levels) received 100 mg/day of CoQ10 along with a 650 kcal/day diet. After 8-9 weeks, the mean weight loss in the CoQ10-deficient group was 13.5 kg, compared with 5.8 kg in those with normal levels of CoQ10.
Because CoQ10 is involved in energy production, it is possible that supplementation might enhance aerobic capacity and muscle performance. In one study,27 six healthy, sedentary men (mean age, 21.5 years) performed a bicycle ergometer test before and after taking CoQ10 (60 mg/day) for 4-8 weeks. CoQ10 treatment improved certain performance parameters, including work capacity at submaximal heart rate, maximal work load, maximal oxygen consumption, and oxygen transport.
Male Infertility
Because sperm production and function are highly energy-dependent processes, CoQ10 deficiency could presumably be a contributing factor to infertility in men, studies have shown that administration of 10-200 mg/day of CoQ resulted in a significant increase in sperm count and motility in a group of infertile men.
Cardiovascular Disease Protection
CoQ10 plays a key role in energy production, and is therefore essential for all energy-dependent processes, including heart-muscle contraction. CoQ10 deficiency has been documented in patients with various types of cardiovascular disease.
Congestive Heart Failure
In a recent double-blind trial. Some 641 patients with CHF were randomly assigned to receive placebo or CoQ10 (2 mg/kg/day) for one year. Conventional therapy was continued in both groups. The number of patients requiring hospitalization during the study for worsening heart failure was 38% less in the CoQ10 group than in the placebo group (p < 0.001). Episodes of pulmonary edema were reduced by about 60% in the CoQ10 group, compared with the placebo group (p < 0.001).
Angina
Patients with stable angina pectoris taken 150 mg/day of CoQ10 or a placebo, each for 4 weeks, in a double-blind crossover trial. CoQ10 treatment significantly increased exercise tolerance on a treadmill, and significantly increased the time until ST-segment depression occurred. Compared with placebo, there was a 53% reduction in the frequency of anginal episodes and a 54% reduction in the number of nitroglycerin tablets needed during CoQ10 treatment. These results suggest that CoQ10 is a safe and effective treatment for angina pectoris.
Arrhythmias
Twenty-seven patients with ventricular premature beats (VPB's) and no evidence of organic heart disease received a placebo for 3-4 weeks, followed by 60 mg/day of coenzyme Q10 for 4-5 weeks. The reduction in VPB's was significantly greater after CoQ10 than after placebo.
Stabilizing Blood Pressure
Twenty-six patients with essential hypertension received coenzyme Q10, 50 mg twice a day. After 10 weeks of treatment, mean systolic blood pressure decreased from 164.5 to 146.7 mm Hg and mean diastolic blood pressure decreased from 98.1 to 86.1 mm Hg (p < 0.001), possibly because of a reduction in peripheral resistance.
Diabetes Mellitus
Diabetes mellitus is a multifactorial disease that is associated with carbohydrate metabolism abnormalities. The electron transport chain, of which CoQ10 is a component, plays a major role in carbohydrate metabolism. A deficiency of CoQ10 might therefore have an adverse effect on glucose tolerance. Thirty-nine diabetics received 120 mg/day of CoQ7 for 2-18 weeks. Fasting blood sugar levels fell by at least 30% in 31% of the patients and the concentration of ketone bodies declined by at least 30% in 59% of the patients.
Migraine Prophylaxis
Patients with recurrent migraines have been reported to have impaired mitochondrial energy production. In double-blind, placebo-controlled study of 42 people who suffered an average of 4.4 migraine attacks per month. After a month of a baseline placebo, patients randomly assigned to the treatment group received 100 mg of CoQ10 three times a day, while the remaining patients continued to receive placebo. The number of migraine attacks per month was reduced in the treatment group from 4.4 to 3.2, with no change in the placebo group.
Periodontal Disease
Although proper oral hygiene is helpful, many people suffer from intractable gingivitis, often requiring surgery and resulting in eventual loss of teeth. Gingival biopsies revealed subnormal tissue levels of CoQ10 in 60% to 96% patients with periodontal disease and low levels of CoQ10 in leukocytes in 86% of cases. These findings indicate that periodontal disease is frequently associated with CoQ10 deficiency .Eighteen patients with periodontal disease received either 50 mg/day of CoQ10 or a placebo in a 3-week, double-blind trial. Results were assessed according to a “periodontal score,” which included gingival-pocket depth, swelling, bleeding, redness, pain, exudate, and looseness of teeth. All eight patients receiving CoQ10 improved, compared to only three of ten receiving the placebo (p < 0.01).
Improve symptoms of Parkinson’s disease
Parkinson’s disease generates an excess of free radicals, and normally produced coenzyme CoQ10 may be consumed by these. Free radicals damage the cardiolipin in mitochondrial membranes, leading to decreased function. In a recent clinical study, patients were randomly assigned to a treatment with 1200 mg/d of coenzyme Q10, or an inactive placebo. Eight months of treatment revealed that patients who had received the CoQ10 were fairing significantly better than those given the placebo. So much so that they exhibited a 44% reduction in disease progression, compared with the placebo group.
Cholesterol-lowering drugs such as simvastatin, atorvastatin and rosuvastatin inhibit the enzyme 3-hydroxy-3-methylglutaryl(HMG)-CoA reductase, which is required for biosynthesis of both cholesterol and CoQ10. Thus, administration of these drugs might compromise CoQ10 status by decreasing its synthesis. In a study, administration of lovastatin to 5 patients receiving CoQ10 for heart failure was followed by a reduction in blood levels of CoQ10 and a significant deterioration of clinical status. Some of these patients improved after the dosage of CoQ10 was increased or the lovastatin was discontinued. These results suggest that people who have low CoQ10 levels and suboptimal cardiac function might develop clinically significant CoQ10 depletion after taking an HMG-CoA reductase inhibitor. Although individuals with high CoQ10 levels and good cardiac function can probably tolerate these drugs better, a case can be made that all patients being treated with HMG-CoA reductase inhibitors should also receive CoQ10 prophylactically.
Quten-Visol: All natural ingredients
Quten-Visol is made of all natural coenzyme Q10. Quten-Visol is free from preservatives, fragrances or artificial colors. Hundreds of clinical studies worldwide found that taking CoQ10 continuously for up to SIX years is totally safe. In Japan, there is ten millions of people taking CoQ10 daily as a dietary supplements.
Each capsule contains
All natural COENZYME Q10…..30mg
Dosage:
:
Daily supplementation: One capsule daily
Antiwrinkles: Three capsules daily
